Ras Downstream Effector GGCT Alleviates Oncogenic Stress

Ras Downstream Effector GGCT Alleviates Oncogenic Stress

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Summary: How cells adapt to oncogenic transformation-associated cellular stress and become fully transformed is still unknown.Here we identified a novel GGCT-regulated glutathione (GSH)-reactive oxygen species (ROS) metabolic pathway in oncogenic stress alleviation.We identified GGCT as a target of oncogenic Ras and that it is required for oncogenic Ras-induced primary mouse cell proliferation and transformation and shades eq 07m in vivo lung cancer formation in the LSL-Kras G12D mouse model.However, GGCT deficiency is compatible with normal mouse development, suggesting that GGCT can be a cancer-specific therapeutic target.

Genetically amplified GGCT locus further supports the oncogenic driving function of GGCT.In summary, our study not only identifies an oncogenic function of GGCT but also identifies a novel regulator of GSH metabolism, with implications for further understanding of oncogenic stress and cancer treatment.: Biological Sciences; Cell Biology; Cancer Subject Areas: photos de carhartt wip store toulouse Biological Sciences, Cell Biology, Cancer.